🌟 Celebrating Chen-Yang’s Recent Achievements

We’re thrilled to share a series of recent accomplishments that spotlight the impactful research and growing recognition of Chen-Yang Su, a valued member of the CERC community. These milestones highlight Chen-Yang’s leadership in interdisciplinary research at the intersection of social science, genomics, and precision medicine.

🏅 Post-Publication Review Selected as Top 5

Chen-Yang’s review titled “Navigating Clues to Success in Academia” was selected as one of the Top 5 submissions in the Tremplin Post-Publication Review "Win and Publish" Competition, chosen by the Tremplin Consortium Board.
📄 Read the review Navigating Clues to Success in Academia
This recognition reflects strong critical engagement with academic work and showcases emerging voices shaping scholarly discourse.

January 2025

Invited Talk – National Taiwan University
Chen-Yang was invited by National Taiwan University to deliver a talk at their Monthly Talks on Poly-omics & Precision Medicine, hosted by Prof. Pei-Lung Chen. This event gathered prominent researchers, including the CEO of Taiwan Biobank, to discuss innovations in genomics and precision medicine.
🎥 Watch the talk: YouTube – NTU Poly-omics Series

Selected for IGES Young Investigators Committee
Chen-Yang was selected by the International Genetic Epidemiology Society (IGES) to serve a two-year term on the Young Investigators Committee (YIC). This leadership role supports the development of early-career researchers in genetic epidemiology.
🔗 More about IGES YIC

May 2025

1st Prize – Oral Presentation & Panelist at QIRC/CQRM
Chen-Yang won First Prize for their oral presentation at the Congrès québécois de recherche sur les MICI (CQRM) / Quebec Inflammatory Bowel Disease (IBD) Research Conference (QIRC).
Additionally, Chen-Yang was invited to participate in a panel discussion with Mark Daly, a leading figure in genomics research.
📄 Abstract attached
📸 Event photos

May 15–16, 2025

Invited Speaker – Advances in Social Genomics Conference
Chen-Yang was invited to present at the Advances in Social Genomics Conference at the University of Wisconsin–Madison. This prestigious invitation included full travel and accommodation support (~$1300 USD), generously sponsored by the National Institute on Aging, the La Follette School of Public Affairs, and the Initiative in Social Genomics
🔗 Conference details: The Advances in Social Genomics Conference – Methods 1, 2025

We applaud Chen-Yang for these well-deserved recognitions and look forward to continued impact from their work at the forefront of genomic social science and health equity research.

Human genetics professor receives Banting Discovery Award

Sirui Zhou, Assistant Professor in the Department of Human Genetics, has been awarded a prestigious 2025 Banting Discovery Foundation’s Discovery Award. The award program recognizes innovative biomedical health research projects led by outstanding new investigators at universities and research institutes in Canada. 

Zhou received the inaugural $30,000 Banting-Canerector Foundation Discovery Award, established to support investigators focused on Ehlers-Danlos Syndrome (EDS) and Hypermobility Spectrum Disorders (HSD), diseases that cause a defect in the human body’s connective tissue.

“It is a tremendous honor to receive the prestigious Banting Discovery Award,” says Professor Zhou. “This support will advance our research to unravel the complex determinants of EDS and HSD. None of this would have been possible without the invaluable collaboration and support of my colleagues in the McGill Canada Excellence Research Chair Program in Genomic Medicine, particularly Dr. Benoît Delabays and Dr. Vincent Mooser—the driving forces behind this program.”

Zhou and her research team aim to uncover the causes of hypermobile Ehlers-Danlos Syndrome (hEDS)—the most common subtype of EDS and one that is poorly understood. The connective tissue disorder causes a wide range of physical and psychological symptoms, including chronic pain, fatigue, joint instability, depression, and anxiety. There is currently no cure for hEDS, and treatment options remain limited to symptom management.

Zhou’s research program will study individuals with hEDS and their family members across Quebec. Using advanced tools to analyze genes, proteins, and metabolites, her team will identify the genetic, environmental, and metabolic factors that contribute to the disorder—laying the groundwork for more targeted and effective approaches to diagnosis, treatment, and management.

Zhou leads the Population Genomics and Multi-Omics lab which is under the umbrella of the Canada Excellence Research Chair (CERC) in Genomic Medicine at McGill. She is also a member of the Qualitative Life Sciences Program and an Investigator at McGill's Victor Phillip Dahdaleh Institute of Genomic Medicine.

The Banting Discovery Awards are awarded for a one-year term. The intent is to provide seed funding so researchers can gather pilot data and enhance their competitiveness for other sources of funding. This is the Banting Discovery Foundation’s 100th cohort of Discovery Award recipients.   

• Last updated: Mon, 06/02/2025 - 12:05

• Source Site: /research

  Article own by McGill Research and Innovation

Category: 

• Medicine and Health Sciences

• Research and innovation

CERC team members at IGES and ASHG conferences in Denver !

Last week was a big week, full of accomplishments, for 9 CERC team members who accompanied Vincent Mooser, CERC Chairholder, to the American Society of Human Genetics (ASHG) annual meeting on Nov 5-9, 2024 in Denver Colorado. One of them also attended the International Genetic Epidemiology Society (IGES) annual meeting on Nov 3-4, 2024, just before ASHG conference.

3 MSc students, 2 PhD students, 2 bioinformaticians and 1 post-doc got their abstract selected for posters presentation. You can find their abstract below:

• MSc students: Alyssa Green, Juliano Malizia, Irene Pender

• PhD students: Peyton McClelland, Thomas Zheng

• Bioinformaticians: Vincent Chapdelaine, Justin Pelletier

• Post-doc: Benoît Delabays

Finally we must congratulate Chen-Yang Su for not one but two big achievements ! His abstracts won 2 awards in each conference ! At IGES, Chen-Yang received the Roger Williams Award Finalist which rewards the top 4 abstracts by a student enrolled in a bachelor, master or PhD program at the IGES Annual Meeting among hundreds of abstract submissions. At ASHG, Chen-Yang was invited to give a talk at the Platform Oral Presentation rewarding the top 10% of abstracts submitted to the conference. Please find his abstracts below:

• IGES

• ASHG

CERC EDI strategy revised

The CERC EDI-in-Action Committee is proud to present the 2nd version of the CERC EDI strategy. The initial CERC EDI strategy outlined five commitments and specific actions. In 2023, the CERC team submitted a 2-page summary of progress on EDI activities for the Tri-agency Institutional Programs Secretariat (TIPS) mid-term report. In 2024, applying TIPS’ mid-term review recommendations, the CERC-EAC decided to revised its EDI Strategy, and associated EDI Workplan/Roadmap until the end of the CERC Program.

The main changes are the following: producing a CERC annual EDI survey, organizing a retreat on EDI in CERC projects related to underrepresented groups, updating the student recruitment processes to improve the representation of Canadian diversity, as well as implementing a targeted recruitment strategy corresponding to various projects' needs. The Program’s EDI Strategy is fundamental and transversal, cutting across the scientific, governance, recruitment, and training facets of the Program. This Strategy is defined by five principal commitments, described below:  

EDI commitments:

1. Ensuring that research projects within the CERC Program include and benefit diverse social groups

2. Equitable representation across ranks/groups among faculty and trainees working in connection with the Program

3. Building an inclusive and respectful climate

4. Developing and implementing an effective mode of receiving disclosures of EDI-related conflicts or challenges

5. Transparency in commitments, metrics, progress, and outcomes

Visit of Ignazio Cassis, Swiss Minister of Foreign Affairs, at McGill University

Mr Ignazio Cassis, Swiss Minister of Foreign Affairs, and a delegation including 3 Ambassadors and 3 Consuls, visited McGill on October 30th, 2024, for a lunch at the Faculty Club. The goal of the meeting was to give to this delegation an overview of McGill and a description of the multi-disciplinary approach that McGill is using to develop and implement genomic medicine. Vincent Mooser, CERC Chairholder, was leading the McGill delegation, including Dominique Bérubé, Vice-Principal (Research and Innovation) and Anja Geitmann, Vice-Principal (Global Engagement). It became immediately apparent during the meeting that genomic medicine is a perfect topic for Diplomacy and Science, an area of high interest for the Swiss Department of Foreign Affairs.

Chen-Yang Su awarded the Best Oral Presentation CMDO Annual Symposium on Health Research and Artificial Intelligence

We would like to congratulate Chen-Yang Su, PhD student of the McGill CERC in Genomic Medicine, who was awarded the Best Oral Presentation at the Cardiometabolic Health, Diabetes and Obesity Research Network (CMDO) Annual Symposium on Health Research and Artificial Intelligence on October 24th, 2024.

You will find the abstract of his presentation below:

Multi-ancestry proteome-phenome-wide Mendelian randomization offers a comprehensive protein-disease atlas and potential therapeutic targets  

Authors 
Su Chen-Yang, MSc *[1,2], van der Graaf Adriaan, PhD [3], Zhang Wenmin, PhD [4], Selber-Hnatiw, Susannah, MSc [2,5], Richards Brent, MD, MSc [5,6,7,8,9], Flannick Jason, PhD [10,11], Zhou Sirui, PhD [2,5], Mooser Vincent, MD [2,5], Lu Tianyuan, PhD [12,13,14,15], Yoshiji Satoshi, MD, PhD [2,5,6,10,11]

Objective: Circulating proteins influence disease risk and are valuable drug targets. To increase the discovery of protein-phenotype associations and identify therapeutic targets for diverse populations, we conducted multi-ancestry proteome-phenome-wide Mendelian randomization (MR), followed by sensitivity analyses and druggability assessment.

Methods: We performed two-sample MR, analyzing 2,265 unique proteins from two platforms (SomaScan v4 and Olink Explore 3072)—2,110 proteins from four European cohorts (n = up to 35,559 individuals), 1,144 from two African cohorts (n = up to 1,871), and 581 from a novel East Asian cohort (n = 1,823). We curated the largest GWAS for 179 traits in Europeans, 26 in Africans, and 206 in East Asians. To reduce horizontal pleiotropy, we ensured instruments were cis-pQTL for the protein of interest and had the highest Open Targets variant-to-gene score. We performed sensitivity analyses including colocalization with PwCoCo and SharePro, a novel method we recently developed. We evaluated shared causal effects of prioritized proteins across ancestries and assessed overlap with the druggable genome, Open Targets, and DrugBank.

Results: We tested 726,035 protein-phenotype pairs in Europeans, 33,078 in Africans, and 115,352 in East Asians. Notably, 119 proteins were instrumentable only in Africans and 17 proteins only in East Asians due to allele frequency differences that are common in these ancestries but rare in Europeans.  We identified 3,949, 56, and 325 unique protein-phenotype pairs in European, African, and East Asian populations, respectively. To showcase our findings, we illustrated the causal role of IL1RL1 in inflammatory bowel diseases, which was supported by multiple lines of evidence.

Conclusion: This study provides the largest multi-ancestry atlas of protein-disease associations, expanding insights into disease etiology and opportunities for prioritizing therapeutic targets. Results are available at the Common Metabolic Diseases Knowledge Portal (https://hugeamp.org/r/protein_mr_atlas).

2024 CERC/C150 Symposium

From October 21 to 23, 2024, Vincent Mooser and Claire Le Moigne attended the 2024 CERC/C150 Symposium hosted by the University of Sherbrooke. This is the 2nd edition of a symposium which was first organized by McGill in June 2021. This event was made possible through a collaboration between the Tri-agency Institutional Programs Secretariat (TIPS) and the UdeS. This conference was gathering CERC and C150 chairholders, CERC team members and employees involved in CERC/C150 application, management and reporting from many Universities in Canada.

Other colleagues from McGill committed with the CERC in Genomic Medicine were also attending the conference:

• Kristina Öhrvall, Assistant Vice-President, Research Development: CERC Oversight Committee and CERC EDI-in-Action committee member

• Magdalena Maslowska, Senior Advisor, Research Development (Biomedical and Health Sciences): CERC EDI-in-Action committee member.

Vincent Mooser chaired a Panel discussion on Preparing the Chairholder for the Canadian Research Environment with the following panelists:

• Sara Hart, Canadian Excellence Research Chair in Developmental Science, University of Waterloo

• Shinichi Nakagawa, Canada Excellence Research Chair in Open Science and Synthesis in Ecology and Evolution, University of Alberta

• Sriram Subramaniam, Canada Excellence Research Chair in Precision Cancer Drug Design, University of British Columbia

Kristina Öhrvall also shared the knowledge and good practices from McGill University during the Panel discussion titled Life Post CERC-C150 - Transitioning out of a CERC or C150.

Raquel Cuella Martin awarded a Gairdner Early Career Investigator Award

The CERC team is pleased to announce that Raquel Cuella Martin, one of its Assistant Professor, was among the five investigators selected by the Gairdner Foundation for a prestigious Early Career Investigator Award ! Cuella Martin will present her research on precision genome engineering ("Understanding unique protein features with precision genome engineering") alongside the 2024 Gairdner Awardees during the Laureate Lecture at the Gairdner Science Week 2024 events in Toronto from October 23 to 25. Learn more.

The CERC team welcomes a new Assistant Professor : Satoshi Yoshiji

The CERC team has the pleasure to welcome a new Assistant Professor in the team, Satoshi Yoshiji.

Satoshi Yoshiji (pronounced “yo-she-gee”) is an Assistant Professor with expertise in endocrinology, genetic epidemiology, and biostatistics. His research goal is to leverage genomics, proteomics, and other omics to identify therapeutic targets and advance precision medicine for diabetes, obesity, cardiovascular diseases, and beyond. After earning board certifications in Endocrinology and Internal Medicine in Japan, he obtained his PhD in Human Genetics at McGill University (Joint PhD with Kyoto University). He worked as a Research Fellow at the Broad Institute of MIT and Harvard before returning to McGill as a Principal Investigator. He serves as a co-PI for BioPortal, a new multi-ancestry, multi-omics biobank of 12,500 individuals in Montreal. He is recruiting ambitious, forward-looking students and staff.

If you want to know more about Satoshi Yoshiji, please consult his personal website here !

Human Genetics Research Day 2024

The CERC team wants to congrats Peyton McClelland for winning the 3-min presentation of the Human Genetics Research Day, organized by the Department of Human Genetics of McGill on May 30, 2024.

Over 150 students and faculty participated to this event, showing the dynamism of Genetics at McGill. Dr. Stephen Scherer for joined the participants as the keynote speaker under the Scriver Family Visiting Professorship in Genetic Medicine, with his talk entitled: “Every biological study will be enlightened by an accompanying genome sequence”.

Peyton presented a 3-min talk titled Investigating HLA in a Quebec population-based biobank about her work in the CERC team on analyzing and imputing HLA in the CARTaGENE biobank to enable cataloguing HLA variation and disease association in the Quebec population.

You will find the whole abstract of the presentation below:

Calling HLA allele variation in the Quebec population-based CARTaGENE cohort using whole-genome sequencing data.

Peyton McClelland, Ken Sin Lo, Guillaume Lettre, Claude Bhérer, Daniel Taliun

The human leukocyte antigen (HLA) system contains genes involved in many immunological processes, and HLA variation is associated with many disease-related phenotypes, including type I diabetes, multiple sclerosis, and rheumatoid arthritis. HLA allele frequencies differ significantly across populations, making population-specific HLA characterisation necessary to understand the HLA variation within a given population. We built a catalogue of high-resolution HLA alleles in the province of Quebec, using high-depth whole-genome sequencing (WGS) data from 2,180 participants from CARTaGENE, a population-based cohort with recruitment centers in six regions of Quebec that has collected high-quality biosamples and extensive health information. We performed HLA typing of class I and II classical alleles using the HLA*LA method. After quality checks, 44,634 alleles were retrieved from 2,088 participants. 307 individual HLA alleles were observed at least once in the CARTaGENE WGS dataset. Of these, 262 HLA alleles were also present in the most extensive publicly available multi-ancestry high-resolution HLA reference panel, HLA-TAPAS (n=21,546). 49 of 262 HLA alleles were at significantly different frequencies in the CARTaGENE cohort (p < 2.15 x 10-4). Frequencies of 51 low-resolution (one-field) HLA allele types were also previously reported in the Hema-Quebec donor biobank in 17 administrative regions of Quebec. We compared regional allele frequencies in CARTaGENE to the Hema-Quebec cohort. In the CARTaGENE WGS dataset, frequencies of 38 shared HLA alleles correlated well with province-wide frequencies in Hema-Quebec (Pearson’s r = 0.9841); 2 alleles were at significantly different frequencies in CARTaGENE (p < 1.32x 10-3). For individual CARTaGENE sampling regions, HLA allele frequencies were well correlated with corresponding Hema-Quebec regions, with Pearson’s r ranging from 0.88-0.93. These preliminary findings suggest that sequencing-based HLA calling in the Quebec population may yield population-specific differences in HLA variation and disease associations, for which specialized methods for population-specific imputation and analysis will be developed.